- WHAT IT DOES -
 
 


Provides The Support Necessary For Restful Sleep*

 

 
 
- PRODUCT DESCRIPTION -
 
 


MELATONIN

What exactly is Melatonin?

"Melatonin is the all-natural nightcap. It's secreted by the pineal gland, a pea-size structure at the center of the brain, as our eyes register the fall of darkness." At night melatonin is produced to help our bodies regulate our sleep-wake cycles. The amount of melatonin produced by our body seems to lessen as we get older. Scientists believe this may be why young people have less problem sleeping than older people.

Melatonin is a natural hormone that’s naturally produced by the pineal gland. As we age, our body produces less and less, making in more difficult to fall asleep. MVP Nutrition’s ® Melatonin pharmaceutical grade with a minimum purity of 99.6%.*

Melatonin is a hormone produced by the pineal gland. Its most recognized function is the adjustment of sleeping patterns (jet-lag). Further, Melatonin has many other outstanding, yet not broadly known, properties that can intensify athletic performance. At night Melatonin is produced to help our bodies regulate our sleep-wake cycles. The amount of melatonin produced by our body seems to lessen as we get older. Scientists believe this may be why young people have less problem sleeping than older people.

Melatonin was first identified forty years ago and is now recognized as one of life's most beneficial molecules. Humans secrete it naturally from the pineal gland (a pea-sized structure located at the center of the brain), in response to light hitting the eyes. Physiologists recognize Melatonin as the hormone that keeps us in sync with the rhythms of the day as well as the season. Through its effect on other hormones, it helps determine when people sleep, animals breed, birds migrate and even when dogs shed their coats.
Melatonin is rapidly gaining recognition as one of the most effective anti-oxidants available. Interpreting the true greatness of this dietary supplement may take years, the most common way of taking Melatonin is simply before going to sleep - as many people who take it will tell you they get exactly what they expect!

Though it was discovered in 1958, it is only recently that melatonin, a hormone produced by the pineal gland, has been intensively studied. In 1993 melatonin made its first appearance as a consumer product hailed for its sleep inducing effect. Melatonin supplements are being investigated as a potential treatment to readjust biorhythms and alter sleep cycles in people with jet lag, the blind, and nightshift workers. It is also being explored for its potential in the treatment and prevention of various diseases.

Melatonin works to maintain the body's circadian rhythms, regulating such human functions as body temperature, dream sleep, the sleep/wake cycle, and the secretion of cortisol. The cue for the release of this hormone begins when the eyes first register the onset of darkness. The body requires darkness to produce melatonin. Thus, levels of this hormone are high at night and low during the day. This chemical is not produced during daytime naps, as light suppresses its production.

Melatonin originates from tryptophan, an essential amino acid which is obtained through the diet. During the day the body converts tryptophan into serotonin (a chemical involved in mood). Serotonin is then converted to melatonin (usually at night). Large doses of tryptophan increase melatonin levels and induce sleep.

Unlike other hormones, melatonin does not need a receptor to enter a cell membrane and can permeate any part of a cell. It is absorbed directly into the bloodstream, other tissues and body fluids. Infants begin producing melatonin about the fourth day after birth. Prior to birth, melatonin passes through the placenta to the infant. This chemical is also present in breast milk.

Melatonin is found in some plants, mammals, birds, reptiles, and amoebas, regulating activities such as mating, migration, and hibernation. Some animals exhibit higher melatonin levels in fall and winter months when the number of daylight hours decreases. This same pattern has been noted in women but not in men. Melatonin levels peak during childhood and gradually decrease throughout adolescence and adulthood. Declining levels of this hormone trigger the onset of puberty in children and menopause in women. Melatonin levels are lowest in older adults, which may explain the prevalence of insomnia in this population.

Sufferers of Seasonal Affective Disorder (SAD) may have high daytime levels of melatonin and consequently abnormal circadian rhythms. SAD is a condition marked by depression associated with the declining level of daytime light during the winter months. Exposure to light, which can alter the timing of melatonin secretion, is found to be therapeutic for this condition.

Melatonin is being considered as a potential treatment for breast cancer because of its ability to limit the amount of estrogen entering cells. High exposure to the hormone estrogen is believed to be the cause of many types of breast cancer. In tests on rats, melatonin has been found to decrease the size of malignant mammary tumors by 50%.1 The effects of melatonin have also been studied when used in conjunction with tamoxifen, another anti-estrogen chemical which is a possible treatment for breast cancer. These studies indicate tamoxifen is 100 times more effective against cancer cells that have previously been treated with melatonin. Research also indicates that patients with high blood levels of melatonin have greater success with chemotherapy.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease


 
 
- Q & A -
 
 

 

Why take it?

"Studies suggest that low-dose supplements can hasten sleep and ease jet lag, without the hazards or side effects of prescription sleeping pills." Melatonin may have many other uses and has been reported to make people feel better, strengthen the immune system, and reduce free radicals in the body. Current research is underway to determine melatonin's effect as an anti-oxidant, immno-modulator in cancer, delayed sleep-phase disorders, and jet lag. Tests are still under way so there is much to still be learned about melatonin and its effects on the human body.

Who benefits the most?

Travelers and people suffering from mild sleep disorders. According to Newsweek, a typical comment from discussion groups on the Internet is, "'Folks, I've tried melatonin and it's great. It has ...restored my sleep cycle, given me lots of energy.'"

iWhat is the recommended dosage?

The appropriate dose can vary enormously from person to person, and successful results have been achieved with dosages ranging from .1 mg (100 mcg) to 200 mg (200,000 mcg). "In controlled clinical studies researchers have found that as little as a tenth of a milligram (100 mcg) makes dozing off easier, whatever the time of day." Start off small (e.g. less than half of a milligram) each night before bed-time, and work your way to larger doses if needed.

What is mg, mcg, and what is the difference?

mcg and mg are units of weight, like ounces and pounds, but are applied to tiny fractions of grams -
1 mcg = 1 microgram = one-millionth ( 1 / 1,000,000 ) of a gram
1 mg = 1 milligram = one-thousandth ( 1 / 1,000 ) of a gram = 1,000 mcg
A 1.5 mg tablet is five times the dosage of a 300 mcg (.3 mg) tablet.

Are there any side effects?

According to one report, "10 percent of the users said the hormone did nothing for them, and another 10 percent complained of side effects such as nightmares, headaches, morning groginess, mild depression, and low sex drive. In past studies, researchers have given people up to 600 to 3,000 times the usual doses - without causing any toxicity."

What additional benefits are there and how reliable are these claims?

"In test-tube and animal experiments, researchers have found that it protects cells, strengthens the immune system and slows the growth of some tumors." Tests with laboratory mice suggest that melatonin might also reduce the effects of aging - but remember, these results are very preliminary. "...Some experts are appalled to see so many people toying with such a potent hormone. One concern is that high doses, while causing no immediate harm, could have unknown long-term effects. 'Even one milligram, the smallest commercially available dose, is at least three times higher than the normal amount in the body.'" (Note: Worldwide Labs supplies a 300 mcg dose.)

Should certain people avoid it?

Yes. "Those include women who are pregnant or nursing (since no one knows how excessive exposure to the hormone might affect a fetus or infant); people with severe allergies or autoimmune diseases (melatonin could exacerbate such conditions by stimulating the immune system); people with immune-system cancers such as lymphoma or leukemia (for the same reason), and healthy children (who already produce it in abundance). Women trying to conceive should also think twice about taking the hormone, since high doses can act as a contraceptive." As with any substance introduced into your body, if you have a medical condition you should always consult your physician first before taking melatonin.

Will melatonin extend my lifespan?

There are no human studies to support this contention. In tests on both rats and mice melatonin caused a significant 20% increase in their lifespan. If melatonin does allow you to live longer and healthier it could do so because melatonin may reduce free radical damage; stimulate an aging immune system; protect the cardiovascular system; preserve a youthful circadian rhythm; stimulate the production of growth hormone.

Will melatonin enhance my sex life?

There is no evidence to support this claim as it relates to humans. However, a 1995 rodent study suggests that taking small amounts of melatonin on a regular basis may prevent the age-related decline in testosterone levels, allowing men to be more active sexually in their later years.

Is melatonin safe?

Melatonin is one of the least toxic substances known. People have taken as much as 6 grams (600 to 3000 times the normal dosage) of the substance in carefully monitored studies with no sign of toxicity. Only four complaints regarding melatonin have been report to the FDA (USA's Food and Drug Administration). The only consistent side effect of high doses has been drowsiness and a slower reaction time. In the most extensive clinical trial to date a high dose of 75 milligrams of melatonin per day was given to 1400 women in the Netherlands for up to four years with no ill effects. The FDA reports that in the more than two years melatonin has been available for sale over-the-counter in the United States, no alarming side effects have been reported.

When should the dosage be administered?

Melatonin should only be taken at nighttime, usually about thirty minutes prior to going to bed. If you are traveling on a long trip you may want to take a low dosage 300mcg tablet prior to getting on your flight and a 1.5mg pill prior to going to bed. If you commonly sleep during the night, melatonin should not normally be taken during the day - and vice versa - because melatonin plays a role in setting the body's daily clock.

Does melatonin have that morning-after hangover effect of sleeping pills?

No. You should normally wake up well refreshed and full of energy. If you wake up feeling a little tired you should reduce your dosage until you wake up feeling well refreshed. You will not have the hangover effect you may experience with over the counter or prescription sleeping pills.

 

 
 
- TECHNICAL SPECIFICATIONS -
 
 


120 capsules - 3 mg

 

 

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