- WHAT IT DOES -
 
 

A High Performance Sustained Nutrient Delivery System

L-phenylalanine serves as a building block for the various proteins that are produced in the body. L-phenylalanine can be converted to L-tyrosine (another amino acid) and subsequently to L-dopa, norepinephrine, and epinephrine. L-phenylalanine can also be converted (through a separate pathway) to phenylethylamine, a substance that occurs naturally in the brain and appears to elevate mood.

D-phenylalanine is not normally found in the body and cannot be converted to L-tyrosine, L-dopa, or norepinephrine. As a result, D-phenylalanine is converted primarily to phenylethylamine (the potential mood elevator). D-phenylalanine also appears to influence certain chemicals in the brain that relate to pain sensation.

DLPA is a mixture of the essential amino acid L-phenylalanine and its mirror image D-phenylalanine. DLPA (or the D- or L-form alone) has been used to treat .1 2 D-phenylalanine may be helpful for some individuals with Parkinson’s disease.3 D-phenylalanine has been used to treat chronic pain—including osteoarthritis and rheumatoid arthritis—with both positive4 and negative5 results. For conditions where D-phenylalanine alone has been shown to be effective, DLPA should also work, as it contains 50% D-phenylalanine.

 

 
 
- PRODUCT DESCRIPTION -
 
 


L-PHENYLALANINE FREE FORM AMINO ACID 500
L-Phenylalanine is an essential, nine-carbon amino acid and is a precursor to the amino acid tyrosine. Because tyrosine is necessary for the synthesis of proteins and the production of the neurotransmitters dopamine and norepinephrine, phenylalanine is an extremely important nutrient that must be obtained through the diet or supplementation.*

Phenylalanine is an essential amino acid that is metabolized into a brain neurotransmitter, norepinephrine, with the help of Vitamins C and B-6. Norepinephrine helps stimulate the release of growth hormone from the pituitary gland and is involved in mood, clarity of thought, and alertness. 

Phenylalanine is a precursor to adrenaline (epinephrine), the adrenal hormone which, along with norepinephrine, regulates the fight or flight response.

Many of the observed effects of phenylalanine relate to mental functioning. This amino acid is experimentally used to improve learning and memory, and as an antidepressant. It promotes feelings of alertness and aids in obesity by suppressing appetite. It forms the artificial sweetener aspartame (Nutrasweet) when chemically combined with aspartic acid.

Phenylalanine is commercially available in two forms, L and DL. The two differ in purpose only in that the DL form lessens pain associated with migraines, premenstrual syndrome (PMS) and arthritis. The D-isomer is incorporated into receptors, thus blocking pain. In his book, Natural Prescriptions, Dr. Robert Giller says that many of his patients have found phenylalanine to be the most exciting PMS treatment he has found for the moodiness and depression that precede a womanís period.

The inability to metabolize phenylalanine results in the metabolic disorder, PKU. Those suffering from this disorder must halt or at least cut back on phenylalanine consumption to prevent serious mental retardation. 

Phenylalanine should not be used by pregnant women, persons with panic disorders, high blood pressure, or pre-existing pigmented melanoma.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease


 
 
- Q & A -
 
 

 

Where are they found? 

L-phenylalanine is found in most foods that contain protein. D-phenylalanine does not normally occur in food. However, when phenylalanine is synthesized in the laboratory, half appears in the L-form and the other half in the D- form. These two compounds can be separated. However, the combination supplement (DLPA) is often used because both components exert different health-enhancing effects.

Who is likely to be deficient? 

Individuals whose diets are very low in protein may develop a deficiency of L-phenylalanine, although this is believed to be very uncommon. However, one does not necessarily have to be deficient in L-phenylalanine in order to benefit from a DLPA supplement.

How much is usually taken?

DLPA has been used in amounts ranging from 75–1,500 mg per day. As this compound can have powerful effects on mood and on the nervous system, DLPA should be taken only under medical supervision.

Are there any side effects or interactions?

The maximum amount of DLPA that is safe is unknown; however, consistent toxicity has not been reported with 1,500 mg per day or less of DLPA, except for occasional nausea, heartburn, or transient headaches.

L-phenylalanine competes with several other amino acids for attachment on a common amino acid carrier in the body. Therefore, it should not be taken with protein-containing foods. Individuals taking prescription or over-the-counter medications should consult a nutritionally oriented physician before taking DLPA.

At the time of writing, there were no well-known drug interactions with L-Phenylalanine and D,L-Phenylalanine.

References:

1. Sabelli HC. Clinical studies on the phenylethylamine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplements. J Clin Psychiatry 1986;47:66–70.
2. Fischer E et al. Therapy of depression by phenylalanine. Arzneimittelforsch 1975;25:132.
3. Heller B et al. Therapeutic action of D-phenylalanine in Parkinson’s disease. Arzneimittelforsch 1976;26:577–79.
4. Budd K. Use of D-phenylalanine, an enkephalinase inhibitor, in the treatment of intractable pain. Adv Pain Res Ther 1983;5:305–8.
5. Anonymous. Phenylalanine fails to help chronic back pain patients. Family Pract News 1987;17(3):37.

 

 
 
- TECHNICAL SPECIFICATIONS -
 
 


Other Ingredients: Gelatin (capsule shell), magnesium stearate, silica, cellulose, calcium silicate.

Contains no: sugar, salt, starch, yeast, wheat, gluten, corn, soy, milk or preservatives.

Suggested Use: As a dietary supplement, take 1 capsule 1 to 3 times a day as needed, preferably between meals.

Warnings: Persons with high blood pressure should consult a physician before using.KEEP OUT OF THE REACH OF CHILDREN. Keep container tightly closed in a cool, dry and dark place. Do not eat freshness packet. Keep in bottle.

 

 

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